Endocrine Abstracts

Objectives: Glucocorticoids (GCs) intervene in different physiological activities in almost all systems of the human organism. However, GCs are also potent inducers of apoptosis in many cell types and tissues. It is known, that glucocorticoid-induced apoptosis affects the musculoskeletal system, circulatory system, nervous system, endocrine system, reproductive system, and the immune system. Nevertheless, the exact mechanisms of GCs action in human normal hematopoiesis are sti...

Objectives: GH plays a crucial role in the regulation of metabolism of human cells. Nevertheless, a direct influence of this hormone on the proliferation, maturation and differentiation of human early hematopoietic stem/progenitor cells (HSPCs) has not been investigated thoroughly. Moreover, certain deviations of hematological parameters, such as anemia or leucopenia, are commonly observed in patients with growth hormone deficiency (GHD) syndrome, which might be substantially ...